How to Find the Best Narcolepsy Medication for You

Best Narcolepsy Medication is the most frequent treatment for narcolepsy patients. They are not a cure, but they would help you overcome this condition’s signs. However, you must take the time to obtain the proper prescription or combination of Best Narcolepsy Medication for you.

Treatments for Narcolepsy

The most effective treatments with the fewest adverse effects are different for each person. Before discovering the proper therapy, you may need to test multiple medicines and dosages. Some drugs let people sleep throughout the day, which might be risky. Other medications target cataplexy, a transient muscular weakness that plagues persons with type 1 narcolepsy. A few medications can help with both problems.


Best Narcolepsy Medication are Armodafinil (Nuvigil) and modafinil  (Provigil). Stimulants are substances that assist you to stay awake and aware. If you suffer minor daytime sleepiness, your doctor may recommend one of these initiatives.

The following are some instances of potential negative consequences:

  • Headache
  • Nausea
  • Anxiety

Birth control pills or other hormonal contraceptives may be affected by armodafinil and modafinil. To reduce your chances of becoming pregnant, use a backup birth control method.


If you have significant excessive daytime sleepiness or armodafinil or modafinil hasn’t helped, your doctor may recommend this more vital stimulant. Amphetamines are a class of drugs that includes the following:

  • Amphetamine and dextroamphetamine mix 
  • Dextroamphetamine
  • Methylphenidate 

Side Effects

The following are possible side effects:

  • Disturbance of sleep
  • Nervousness
  • Shakiness
  • Heartbeats that aren’t regular

If you have blood pressure or heart problems, these drugs may not suit you. 

Gamma-Hydroxybutyrate (GHB)

Drugs aid in deep sleep at night, allowing you to be less sleepy and more awake throughout the day. If you experience frequent cataplexy attacks, your doctor may initially prescribe medication. You should take one dose shortly before going to bed and another three to four hours later. Alcohol, narcotic pain medications, and other sedatives are prohibited. You may experience breathing difficulties, coma, or death if you do.

The FDA has authorized three GHB formulations to treat narcolepsy. Both include sodium oxybate, strong medicine that has the potential to become addictive. GHB, or date rape drug, is another name for sodium oxybate, a liquid some individuals take illegally to become euphoric.

Sodium oxybate, calcium, magnesium, potassium

Many of the same adverse effects as Xyrem can occur with this newer medicine. However, it has 90% less salt than the previous medicine.

Sodium oxybate 

It can make you dizzy, upset your stomach, wet the bed, or sleepwalking. It also contains a lot of salt. If you have blood pressure and kidney issues, then it  may not be suitable for you.


Pitolisant Side effects include nervousness or dizziness, as well as fainting and an irregular heartbeat. Serious adverse effects are uncommon. However, hallucinations are a possibility.


Several distinct sorts can cure cataplexy. It might assist with the sleep disorder and hallucinations that narcolepsy might induce around bedtime. Antidepressants include the following:

  • Selective serotonin reuptake inhibitors (SSRIs) 
  • Reuptake inhibitors for serotonin and norepinephrine (SNRIs)
  • Tricyclic antidepressants (TCAs) 

TCAs are older medicines that can produce constipation, dry mouth, and lightheadedness. Weight gain, sleeplessness, and digestive issues are possible side effects of SSRIs and SNRIs.


In 2019, this medication was licensed to treat severe sleep disturbance. Headache, nausea, reduced appetite, sleeplessness, and anxiety are the most prevalent adverse effects. Unlike several other narcolepsy drugs, it does not interfere with the effectiveness of birth control tablets. If you have high blood pressure, heart disease, or mental instability, it may not suit you.

Antagonist/Inverse Agonist for the Histamine 3 Receptor

This medicine causes your body to generate more histamine, a brain chemical that promotes alertness.


It’s used to treat sleepiness and fatigue. It may also help to avoid cataplexy attacks. Pitolisant is unlikely to be habit-forming. Headache, nausea, anxiety, insomnia, and heart problems are possible adverse effects. If you have liver or renal problems or certain cardiac disorders, it may not be suitable for you.

Other viable narcolepsy therapies are being researched for approval. Drugs targeting the histamine chemical system, hypocretin replacement, gene therapy, and immunotherapy are among them.

When Should You Consult Your Doctor?

Ask your doctor if something else would work better if your present drugs aren’t controlling your daytime sleepiness or other symptoms well enough. Changing the dose, switching to a different medicine, or mixing best narcolepsy medications are possibilities. Also, tell your doctor if any negative effects are affecting you.


  • Sleep Foundation: “Narcolepsy: Medication and Treatment,” “Narcolepsy: Cataplexy,” “Narcolepsy: Medications for Sleepiness.”
  • Healthy Sleep (Division of Sleep Medicine at Harvard Medical School): “Narcolepsy Medications,” “Narcolepsy: Changes Across the Lifespan.”
  • CNS Drugs: “Recently approved and upcoming treatments for narcolepsy.”
  • Mayo Clinic: “Narcolepsy,” “Pitolisant (Oral Route).”
  • MedlinePlus: “Modafinil,” “Armodafinil,” “Sodium Oxybate.”
  • National Institute of Neurologic Disorders and Stroke: “Narcolepsy Fact Sheet.”
  • Nature and Science of Sleep: “Living with narcolepsy: Current management strategies, future prospects, and overlooked real-life concerns.”
  • Regulatory Affairs Professional Society: “FDA Approvals Roundup: Xywav, Qutenza, Orphengesic.”
  • FDA: “Full Prescribing Information: Xywav,” “Full Prescribing Information: Wakix,” “Full Prescribing Information: Sunosi.”
  • TeensHealth: “GHB.”
  • Medscape: “FDA Okays Pitolisant (Wakix) for Narcolepsy.”


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